Redefining Reference Standards

HDx™ Reference Standards
Identify and Control Variability Every Day

Fluorescence In-Situ Hybridization

Identify and Control Variability within Fluorescence In-Situ Hybridization Assays

Fluorescence-based In-situ Hybridization (FISH) is used to visualize DNA or localized RNA in cells, tissues and tumors. Providing a reliable means for studying the genetic composition of cells in mitosis as well as interphase, with high detection sensitivity and capacity for multiplicity, FISH is also frequently used to demonstrate the presence of cancer gene rearrangements characteristic of certain hematologic malignancies.

View FISH HDx Reference Standards for Fluorescence In-Situ Hybridization  

Two main components are required in the preparation of a FISH assay: the DNA probe and the target DNA to which the probe will be hybridized. To date, a wide range of commercially available probes have been developed for a number of common targets, however their reliable use requires stringent validation and routine monitoring of assay performance.  Consistent and well-validated reference materials are therefore essential to ensure accuracy.

.
Operator Variability
Pre-Analytical
Analytical
.
Sample FFPE Pepsin Treatment  Probe Hybridisation Microscope Diagnosis

Variability within a standard FISH based workflow

Products

Horizon Diagnostics has worked closely with the key European and US pathology proficiency schemes, FISH laboratories and biotech companies to develop  FISH HDx Reference Standard slides. The reference materials are provided in cell culture spread or formalin-fixed, paraffin embedded (FFPE) sections as appropriate for the tumor type being evaluated.  

Key Features

  • Defined chromosomal abnormalities
  • Custom FISH HDx Reference Standards available upon request
  • Genomic materials of FISH HDx Reference Standards available upon request
  • Available as FFPE sections, interphase nuclei, and custom metaphase spreads
  • Validated using FISH

Applications

  • FISH assay performance monitoring
  • DNA probe validation
  • SISH, CISH and other related techniques

Paragraph explaining benefits of Biocair

×

Login Error


There was an error with your login - please try again.

Forgotten your password? Click here

OK ×

Recover your password

Please enter your email address and we'll send you a reset link

×

Thank you.


We've sent you an email to reset your password.

OK ×

Add Voucher


Sorry, Unable to add voucher

OK ×

Account Error


There was an error updating your details.

OK ×

Thank you.


Your changes have been saved.

OK ×

Thank you


Thank you for registering to the Horizon DX website. We hope you enjoy and benefit from our online resources, and please feel free to contact us if you have any queries or feedback through the website itself or at info@horizondx.com.


×

Thank you.


Items have been saved to your basket.

OK ×