Redefining Reference Standards

How do you monitor for variability in your workflow?
Identify and control variability in your laboratory every day


You are here: Home / Connect With Us / Webinars

The following complimentary webcasts are scheduled. Please register to participate.

Please be aware that webinars are hosted through GoToWebinar. If you are not already set up to view webinars through this service, please allow 5 minutes before the start to establish access.

Register for upcoming webinars here:

The Effects of Formalin on Clinical Diagnostics

Date: December 11th, 2014
Time: 16:00-16:40 BST (London time)

Register your place here


The use of formalin fixative stems from its ability to cross-link proteins, however it has also been reported to induce methylol modifications and acid-mediated hydrolysis which can confound genotyping analysis. Similarly, variability in the fixation time, delay of fixation and type of fixation effect tumor biopsies and subsequent sequencing.

Here, we present the design and validation of our Formalin-Compromised HDx Reference Standards with precisely defined molecular weights that mimic formalin-treated samples and their performance in assays.

We will discuss the effects of formalin on clinical diagnostics and how these can be minimized.


  • What is the effect of formalin?
  • How does this effect translate into the clinic?
  • What is the impact on the specificity and sensitivity of NGS?

Meet the presenters

Jonathan Frampton, PhD

In his role, Jonathan works closely with a broad range of European, North American and EMEA oncology-focussed Quality Assurance Schemes with the goal of driving the standardization and normalization of molecular assays across the globe.Jonathan holds a PhD from University of Sussex in Genomic DNA Damage and Stability and has extensive product development experience through previous roles including Cambridge-based antibody company Abcam.

Hadas Amit, PhD

Hadas is a senior scientist with a strong interest in the future of personalised medicine with focus on advances in cell free tumor DNA (cfDNA). Hadas is leading the research and development of cfDNA Reference Standards at Horizon Diagnostics. 


Who should attend?

This webinar is aimed at molecular pathologists and for all those involved in any part of Quality Control.


Contact Horizon Diagnostics

For all technical enquiries, please contact us at


About Horizon Diagnostics

Horizon Diagnostics, a business unit of Horizon Discovery Group plc is proud to support clinical laboratories with the provision of reference materials for research use; applications include the validation of equipment and consumables offline from patient testing. HDx™ Reference Standards are manufactured within a Quality Management System which complies with the requirements of ISO 9001:2008 and ISO 13485:2003.

Paragraph explaining benefits of Biocair


Login Error

There was an error with your login - please try again.

Forgotten your password? Click here

OK ×

Recover your password

Please enter your email address and we'll send you a reset link


Thank you.

We've sent you an email to reset your password.

OK ×

Add Voucher

Sorry, Unable to add voucher

OK ×

Account Error

There was an error updating your details.

OK ×

Thank you.

Your changes have been saved.

OK ×

Thank you

Thank you for registering to the Horizon DX website. We hope you enjoy and benefit from our online resources, and please feel free to contact us if you have any queries or feedback through the website itself or at


Thank you.

Items have been saved to your basket.

OK ×